PEA FOR TOPICAL USE
The lipophilic nature of PEA severely limits its solubility, both in water and in solvents and oil compounds. It is therefore a molecule with low bioavailability, a characteristic that complicates the development of its applications.
PEA
Palmitoylethanolamide (“PEA”) is a palmitic acid amide belonging to the class of ALIAmides* (endocannabinoid-like), lipid agonists of nuclear receptors. It is an endogenous molecule with local action, synthesised within the cell bilayer.
It is believed that PEA is produced as a pro-homeostatic protective response to cellular damage and is generally upregulated in disease states. Its diverse properties, including anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects, stem from unique mechanisms of action that influence numerous processes at different sites; these include the activation of nuclear receptor alpha by the peroxisome proliferator-activated receptor (PPAR-a) and other receptors, including cannabinoid receptors. In addition, PEA regulates transient receptor potential vanilloid 1 (TRPV1) channels, producing a significant desensitising effect.
ALIA
*ALIA = Autacoid Local Injury Antagonism - This is the acronym used by a team of Italian researchers, led by Nobel Prize winner for Medicine Rita Levi Montalcini, to identify a group of endogenous bioactive lipids (ALIAmides) that play a central role in numerous biological processes, including pain, inflammation and lipid metabolism (action on mast cells).
Comparison of images obtained with an optical microscope (100x magnification) showing: a conventional emulsion with high-concentration PEA (image 1) where the presence of undissolved crystals, not perceptible to the touch, is clear- an emulsion made with pealiquitechTM technology (image 2) where PERFECT SOLUBILISATION OF THE HIGH-CONCENTRATION ACTIVE INGREDIENT is clear.
THE USE OF PEA IN GYNAECOLOGY
