Certified Product

Alyval Regenera

Intimate cream. Special formula that helps repair and regenerate delicate tissues in the area.

Special formula that helps repair and regenerate delicate tissues in the area. Special formula for treating the intimate area. Helps repair and regenerate the delicate tissues in the area thanks to a moisturising and soothing action on stressed and atrophic skin, for lasting wellbeing. Promotes the restoration of elasticity and tone.

COMBINED USE WITH Alyval VITAL CLEANSER IS RECOMMENDED

Adjuvant in the treatment of lichen sclerosus and in cases of atrophied tissues.

Contributes to the restoration of skin tissues following surgery or pharmacological treatment

Improves tissue elasticity and tone

Reduces vaginal dryness, ideal in cases of reduced lubrication

Certified Product

FRAGRANCE
FREE

GYNECOLOGICALLY
TESTED

VEGAN
PRODUCT

Adjuvant in the treatment of lichen sclerosus and in cases of atrophied tissues.
Contributes to the restoration of skin tissues following surgery or pharmacological treatment.
Improves tissue elasticity and tone.
Reduces vaginal dryness, ideal in cases of reduced lubrication

Apply the product directly to the affected area as needed and lightly massage. External use.

pealiquitech™
BIOSACCHARIDE GUM-2 - This is a polysaccharide obtained by bacterial fermentation; it acts as a ‘biological shield’ modulating the inflammatory response and protecting the skin from damage caused by external irritants.
TOCOTRIENOLS - These compounds belonging to the vitamin E family, with up to 40 times more antioxidant power than other available forms, protect cellular DNA from oxidative damage and stimulate skin regeneration by promoting collagen synthesis and improving skin elasticity.
HYALURONIC ACID - The particular form of high molecular weight hyaluronic acid used in this formulation, known for its ability to retain large amounts of water, creates a protective and hydrating barrier on the skin's surface.

The innovative pealiquitech™ technology uses a PEA solubilisation process that enables high-concentration cosmetic use in an active, bioavailable form. ALYVAL uses a proprietary patent based on pealiquitech™ technology for the use of PEA in topical formulations.

Vulvar lichen sclerosus (VLS) is a chronic inflammatory disease that primarily affects the skin and mucous membranes of the anogenital region, significantly impacting patients' quality of life.
The standard treatment currently prescribed involves potent topical corticosteroids, the prolonged use of which may pose several risks, including skin atrophy. Additionally, due to the chronic nature of VLS, recurrence is common after treatment has ended.
A randomised double-blind placebo-controlled study, carried out at the Obstetrics and Gynaecology Unit of the IRCCS Policlinico San Martino in Genoa (Italy), was conducted on 100 women with VLS to evaluate the efficacy of ALYVAL REGENERA on this pathology in the long term (36 weeks) following a 12-week course of topical corticosteroids.
The primary efficacy endpoint is relapse rate, while the secondary endpoint is mean time to relapse. In addition to the subjective assessment of symptoms such as itching, burning and dyspareunia asked of the patients, objective evaluations of clinical signs such as erythema, leucoderma, sclerosis and hyperkeratosis were performed.

63 patients completed the first 3 months of maintenance therapy with daily application (31 study group, 32 control group). The group treated with ALYVAL REGENERA reported higher satisfaction than the control group (61.3% vs 25.0%; p=0.004) and a significantly lower recurrence rate (12.5% vs 29.0%; p=0.04).

In patients treated with ALYAVL REGENERA, there is a lower incidence of subjective symptoms (itching, burning and dyspareunia) compared to the control group. Additionally, a reduced incidence of hyperkeratosis (an objective parameter) is observed, on average almost halved compared to the placebo group.